《老化與疾病》(A&D)是一份經(jīng)同行評(píng)審的開放獲取的在線期刊，致力于發(fā)表有關(guān)衰老生物學(xué)、與年齡相關(guān)疾病的病理生理學(xué)和折磨老年人的疾病的創(chuàng)新療法等核心問題的新穎和高影響力的研究成果。感興趣的疾病包括(但不限于)中風(fēng)、阿爾茨海默病、帕金森病、癲癇、癡呆、抑郁癥、心血管疾病、癌癥、關(guān)節(jié)炎、白內(nèi)障、骨質(zhì)疏松癥、糖尿病和高血壓。歡迎對(duì)動(dòng)物模型以及人體組織或細(xì)胞進(jìn)行研究。下列領(lǐng)域的手稿特別值得注意:(A)老化生物學(xué):基因和蛋白質(zhì)表達(dá)的潛在變化機(jī)制基因、突變、影響壽命和成功衰老的信號(hào)通路干細(xì)胞增殖、分化和衰老的機(jī)制壓力在機(jī)體和細(xì)胞水平上的作用跨物種的比較力學(xué)研究認(rèn)知和體育鍛煉對(duì)長(zhǎng)壽和衰老的作用飲食補(bǔ)充劑對(duì)壽命和衰老的影響(B)與年齡有關(guān)的疾病的病理生理學(xué):使用細(xì)胞和分子方法的疾病病理學(xué)影響疾病發(fā)生、病理和進(jìn)展的外在和內(nèi)在因素體育鍛煉和環(huán)境豐富對(duì)疾病進(jìn)展的影響(C)治療老年人疾病的新方法使用特定的干細(xì)胞、祖細(xì)胞或前體細(xì)胞的細(xì)胞療法使用細(xì)胞移植或特定載體的基因治療藥物、維生素、激素和抗氧化劑治療疾病的效果

Aging & Disease (A&D) is a peer reviewed, open access online journal that aspires to publish novel and high-impact findings on central issues pertaining to the biology of aging, pathophysiology of age-related diseases, and innovative therapies for diseases afflicting the elderly population. The diseases of interest include (but not limited to) Stroke, Alzheimer''''s disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes and Hypertension. Studies on animal models as well as human tissues or cells are welcome.Manuscripts in the following areas are of particular interest:(A) Biology of Aging: Mechanisms underlying changes in gene & protein expression Genes, mutations, signaling pathways affecting longevity and successful aging Mechanisms underlying stem cell proliferation, differentiation and senescence Role of stress at organismal and cellular levels Comparative mechanistic studies across species Efficacy of cognitive and physical exercises on longevity and aging Effects of dietary-supplements on longevity and aging (B) Pathophysiology of Age-related Diseases: Disease pathology using cellular and molecular approaches Extrinsic and intrinsic factors influencing disease onset, pathology & progression Effects of physical exercise and environmental enrichment on disease progression (C) Novel treatments for Diseases afflicting the elderly Cellular therapies using specific stem, progenitor or precursor cells Gene therapies using cell grafts or specific vectors Effects of drugs, vitamins, hormones and antioxidants for treatment of diseases