疾病模型與機(jī)制（DMM）發(fā)布了最初的研究、資源和邀請(qǐng)?jiān)u論，重點(diǎn)是使用模型系統(tǒng)更好地理解、診斷和治療人類(lèi)疾病。DMM的主要目的是通過(guò)促進(jìn)基礎(chǔ)研究人員和臨床研究人員在轉(zhuǎn)化科學(xué)方面的合作來(lái)促進(jìn)人類(lèi)健康。該雜志致力于提出符合這一目標(biāo)的非常重要的研究。DMM的跨學(xué)科性質(zhì)意味著各種各樣的疾病、方法和模型都在其范圍內(nèi)。DMM內(nèi)容示例：顯著促進(jìn)我們對(duì)人類(lèi)疾病機(jī)制、診斷或治療的理解的基礎(chǔ)研究，具有廣泛的相關(guān)性。使用模型系統(tǒng)的候選療法的藥物篩選和臨床前分析介紹經(jīng)過(guò)徹底驗(yàn)證的新模型，以證明其在疾病研究中的實(shí)用性。*為疾病和/或示范社區(qū)提供廣泛有用工具的新方法和資源針對(duì)生物醫(yī)學(xué)科學(xué)中當(dāng)前和新興主題的全面、專(zhuān)家評(píng)論和海報(bào)翻譯研究領(lǐng)域的主要科學(xué)家訪談?dòng)懻摳鼜V泛的社會(huì)關(guān)注問(wèn)題的社論，包括監(jiān)管、倫理和政策問(wèn)題整理與特定病區(qū)或模式系統(tǒng)有關(guān)的文章的特別收藏*一般不考慮出版說(shuō)明性的工作，例如說(shuō)明一個(gè)示范系統(tǒng)的特點(diǎn)，而不表明其對(duì)促進(jìn)某一領(lǐng)域的作用，除非編輯小組考慮到新的模式本身，以便更好地了解疾病的機(jī)制和(或)證明對(duì)評(píng)價(jià)治療方法有明確的用處。感興趣的模型系統(tǒng)包括：脊椎動(dòng)物，如小鼠、斑馬魚(yú)、青蛙、大鼠和其他哺乳動(dòng)物無(wú)脊椎動(dòng)物，如黑腹果蠅和秀麗隱桿線蟲(chóng)獨(dú)特的體外或體外模型，如基于干細(xì)胞的模型、基于患者材料的器官和系統(tǒng)微生物，如酵母和盤(pán)基網(wǎng)柄菌其他與人類(lèi)疾病研究有關(guān)的生物系統(tǒng)感興趣的疾病領(lǐng)域包括：癌癥神經(jīng)退行性疾病和神經(jīng)系統(tǒng)疾病精神疾病代謝紊亂，包括糖尿病和肥胖心血管疾病、中風(fēng)和高血壓胃腸道疾病傳染病自身免疫和炎癥發(fā)育性疾病肌肉骨骼疾病腎臟或肝臟疾病眼部疾病藥物和生物標(biāo)志物的發(fā)現(xiàn)/篩選再生醫(yī)學(xué)中的干細(xì)胞療法

Disease Models & Mechanisms (DMM) publishes original research, resources and invited reviews that focus on the use of model systems to better understand, diagnose and treat human disease. The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science. The journal is committed to presenting highly significant research that meets this goal. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its scope.Examples of DMM content:Basic research that significantly advances our understanding of human disease mechanisms, diagnosis or treatment, and is of broad relevanceDrug screens and preclinical analyses of candidate therapies using model systemsPresentation of new models that have been thoroughly validated to demonstrate their utility in disease studies* New methods and resources that provide broadly useful tools for a disease and/or model communityComprehensive, expert reviews and posters addressing current and emerging themes in biomedical scienceInterviews with leading scientists in translational researchEditorials that discuss wider issues of interest to the community, including regulatory, ethical and policy issuesSpecial collections that collate articles relating to a particular disease area or model system *Descriptive work, such as the characterisation of a model system without demonstration of its usefulness to advance a field, is generally not considered for publication, unless the new model itself is considered by the Editorial team to provide an improved understanding of the disease mechanism and/or to demonstrate clear usefulness for the evaluation of treatment approaches. Model systems of interest include:Vertebrates such as mice, zebrafish, frogs, rats and other mammalsInvertebrates such as Drosophila melanogaster and Caenorhabditis elegans Unique in vitro or ex vivo models, such as stem-cell-based models, organoids and systems based on patient materialMicroorganisms such as yeast and DictyosteliumOther biological systems with relevance to human disease researchDisease areas of interest include:CancerNeurodegenerative and neurological diseasesPsychiatric disordersMetabolic disorders, including diabetes and obesityCardiovascular diseases, stroke and hypertensionGastrointestinal diseasesInfectious diseasesAutoimmunity and inflammationDevelopmental diseasesMusculoskeletal disordersRenal or liver diseaseEye disordersDrug and biomarker discovery/screeningStem cells therapies in regenerative medicine