《病原體與疾病》發表了關于病原體、宿主與病原體相互作用、宿主對感染的反應及其分子和細胞相關性的假設和發現驅動的研究的杰出的初步研究。它涵蓋了所有的病原體-真核生物，原核生物，和病毒-并包括人畜共患病病原體和實驗翻譯應用。

Pathogens and Disease publishes outstanding primary research on hypothesis- and discovery-driven studies on pathogens, host-pathogen interactions, host response to infection and their molecular and cellular correlates. It covers all pathogens – eukaryotes, prokaryotes, and viruses – and includes zoonotic pathogens and experimental translational applications.