《糖尿病》雜志發表了關于糖尿病生理學和病理生理學的原創研究。提交的手稿可以報告實驗室、動物或人類研究的任何方面。重點研究糖尿病的發病機制及其并發癥，正常和病理胰島功能和中間代謝，藥物和激素作用的藥理機制，正常和異常生物過程的生化和分子方面的研究報告。在糖尿病教育領域的研究或對糖尿病患者應用公認的治療和診斷方法尚未發表。

Diabetes publishes original research about the physiology and pathophysiology of diabetes mellitus. Submitted manuscripts can report any aspect of laboratory, animal, or human research. Emphasis is on investigative reports focusing on areas such as the pathogenesis of diabetes and its complications, normal and pathologic pancreatic islet function and intermediary metabolism, pharmacological mechanisms of drug and hormone action, and biochemical and molecular aspects of normal and abnormal biological processes. Studies in the areas of diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus are not published.