《美國生理學雜志-肺細胞和分子生理學》發表了涵蓋細胞和呼吸系統組件正常和異常功能的分子、細胞和綜合方面的原始研究。感興趣的領域包括鼻子和鼻竇、傳導氣道、肺循環、肺內皮和上皮細胞、胸膜、肺中的神經內分泌和免疫細胞、參與呼吸控制的神經細胞以及橫膈膜和胸肌細胞。本雜志將涵蓋的過程包括氣體交換、細胞水平的代謝控制、細胞內信號傳導、基因表達、基因組學、大分子及其轉換、細胞與細胞基質的相互作用、細胞運動、分泌機制、膜功能、表面活性劑、基質組分、粘液和襯里材料、細胞內信號傳導、基因表達、基因組學、大分子及其轉換、細胞與基質的相互作用、細胞活力、分泌機制、膜功能、表面活性劑、基質組分、粘液和襯里材料、肺防御、巨噬細胞功能、鹽、水和蛋白質的運輸、呼吸系統的發育和分化以及對環境的反應。歡迎在細胞和器官生理學、分子和細胞生物學、分子遺傳學、基因組學（包括整合功能的動物模型）、生物化學、生物物理學和形態學等領域采用創新方法進行研究的報告。該雜志還將鼓勵在器官、細胞和分子水平（包括對人類受試者的研究）上提交呼吸系統病理生理學的新發現。

The American Journal of Physiology - Lung Cellular and Molecular Physiology publishes original research covering the broad scope of molecular, cellular, and integrative aspects of normal and abnormal function of cells and components of the respiratory system. Areas of interest include the nose and sinuses, conducting airways, pulmonary circulation, lung endothelial and epithelial cells, the pleura, neuroendocrine and immunologic cells in the lung, neural cells involved in control of breathing, and cells of the diaphragm and thoracic muscles. The processes to be covered in the Journal include gas exchange, metabolic control at the cellular level, intracellular signaling, gene expression, genomics, macromolecules and their turnover, cell-cell and cell-matrix interactions, cell motility, secretory mechanisms, membrane function, surfactant, matrix components, mucus and lining materials, lung defenses, macrophage function, transport of salt, water and protein, development and differentiation of the respiratory system, and response to the environment. Reports of research using innovative approaches in cell and organ physiology, molecular and cell biology, molecular genetics, genomics including animal models of integrative function, biochemistry, biophysics, and morphology are welcome. The Journal will also encourage novel submission of findings of the pathophysiology of the respiratory system at organ, cellular and molecular levels including studies in human subjects.