《美國生理學雜志：腎臟生理學》出版了有關腎臟、泌尿系統及其各自的細胞和血管系統，以及控制體液體積和成分的各種主題的原稿。研究可能涉及人類或動物模型、單個細胞類型和孤立的膜系統。鼓勵作者提交使用廣泛方法研究這些系統功能的研究報告，如生物化學、免疫學、遺傳學、數學建模、分子生物學和生理學方法。論文的病理生理基礎上的疾病進程的腎臟，尿路和體液調節也受到鼓勵。

The American Journal of Physiology: Renal Physiology publishes original manuscripts on a broad range of subjects relating to the kidney, urinary tract, and their respective cells and vasculature, as well as to the control of body fluid volume and composition. Studies may involve human or animal models, individual cell types, and isolated membrane systems. Authors are encouraged to submit reports on research using a wide range of approaches to the study of function in these systems, such as biochemistry, immunology, genetics, mathematical modeling, molecular biology, and physiological methodologies. Papers on the pathophysiological basis of disease processes of the kidney, urinary tract, and regulation of body fluids are also encouraged.