該雜志在空氣、灰塵、沉積物、土壤和水中的環境污染物以及環境中的自然毒素的毒性和毒理學領域發表文章。特別值得注意的是:藥物、工業有機物、農用化學品等人為化學品以及消毒和焚燒廢水產生的氯化化合物等副產品的毒性或生物破壞性影響;天然毒素及其影響;有毒化合物的生物轉化和代謝，毒素積累或生物降解的食物鏈;毒性、內分泌紊亂、致突變性、致癌性、生態系統影響和健康危害的測定;環境及公眾健康風險評估，環境指引，有毒物質環境政策。

The journal publishes in the areas of toxicity and toxicology of environmental pollutants in air, dust, sediment, soil and water, and natural toxins in the environment.Of particular interest are:Toxic or biologically disruptive impacts of anthropogenic chemicals such as pharmaceuticals, industrial organics, agricultural chemicals, and by-products such as chlorinated compounds from water disinfection and waste incineration;Natural toxins and their impacts;Biotransformation and metabolism of toxigenic compounds, food chains for toxin accumulation or biodegradation;Assays of toxicity, endocrine disruption, mutagenicity, carcinogenicity, ecosystem impact and health hazard;Environmental and public health risk assessment, environmental guidelines, environmental policy for toxicants.